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Microfluidic cell chips for high-throughput drug screening

The current state of screening methods for drug discovery is still riddled with several inefficiencies. Although some widely used high-throughput screening platforms may enhance the drug screening process, their cost and oversimplification of cell-drug interactions pose a translational difficulty. M

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Lab-On-A-Chip Devices and High Throughput Screening

Wide field-of-view lens-free fluorescent imaging on a chip. We demonstrate an on-chip fluorescent detection platform that can simultaneously image fluorescent micro-objects or labeled cells over

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Brain-on-a-chip Devices for Drug Screening and Disease

2021-9-5  Patient-derived neurons from different regions of the brain can be directly grown and differentiated on a brain-on-a-chip device where the disease development, progression and pharmacological treatments can be studied and monitored in real time.

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Organ-on-a-chip Drug screenIng device to tArget braiN

2020-11-1  Brain organ-on-a-chip drug screening device. Show the project objective. Programme(s) H2020-EU.1.1. EXCELLENT SCIENCE European Research Council (ERC) Topic(s) ERC-2019-POC ERC Proof of Concept Grant ; Call for proposal. ERC-2019-PoC See other projects for this call .

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Microfluidic Liver-On-a-Chip devices for more accurate

Microfluidic Liver-On-a-Chip devices for more accurate drug toxicity screening in preclinical settings The pharmaceutical industry can see a significant boost by the development of in vitro models with better predictive potentials for drug toxicity screening.

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Risk assessment on-a-chip: a cell-based microfluidic

Risk assessment on-a-chip: a cell-based microfluidic device for immunotoxicity screening† Arianna Oddo, ae Mariana Morozesk,ab Enzo Lombi, c Tobias Benedikt Schmidt, ad Ziqiu Tong *ae and Nicolas Hans Voelcker *aefg Nanomaterials are widely used in industrial and clinical settings due to their unique physical and chemical

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Cell-based high content screening using an integrated

This device consists of multiple drug gradient generators and parallel cell culture chambers, in which the processes of liquid dilution and diffusion, micro-scale cell

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Advanced continuous-flow microfluidic device for parallel

2021-5-26  A flow-controlled microfluidic device for parallel and combinatorial screening of crystalline materials can profoundly impact the discovery and development of active pharmaceutical ingredients and other crystalline materials.

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A Rapid Screening Method for Wound Dressing by

2012-6-8  A Rapid Screening Method for Wound Dressing by Cell‐on‐a‐Chip Device Qilong Zhao CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China

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A Precise Microfluidic Assay in Single‐Cell Profile for

2020-4-19  The on-chip screening results were all verified by the patch-clamp assay except for the inhibitory effect of the A-31 on TRPV3 channel. Therefore, the single-cell arrayed microchip dramatically reduces the false-positive/negative results of the conventional FlexStation 3 screening from 76.2% (16/21) to 4.8% (1/21).

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Tissue Chip for Drug Screening National Center for

2021-8-2  The Tissue Chip for Drug Screening program aims to develop bioengineered devices to improve the process of predicting whether drugs will be safe or toxic in humans. Learn more. New Clinical Trials on a Chip Program Could Improve Drug Development Process. To improve the success rate of late-stage clinical trials of investigational drugs, the new

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Dynamic screening and printing of single cells using a

2020-2-17  Dynamic screening and printing of single cells using a microfluidic chip with dual microvalves This device enables dynamic regulation of both the lower and the upper size limits of cells for printing. It has significant application potential in inoculating cells with desired sizes for various fields such as clonal expansion, monoclonality

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Brain-on-a-chip Devices for Drug Screening and Disease

2021-9-5  Organ-on-a-chip platforms have the potential to strongly impact and improve the drug screening process by recreating in vitro the functionality of human organs. Patient-derived neurons from different regions of the brain can be directly grown and differentiated on a brain-on-a-chip device where the disease development, progression and

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Microfluidic Liver-On-a-Chip devices for more accurate

Microfluidic Liver-On-a-Chip devices for more accurate drug toxicity screening in preclinical settings. The pharmaceutical industry can see a significant boost by the development of in vitro models with better predictive potentials for drug toxicity screening

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Cell-based high content screening using an integrated

High content screening (HCS) has quickly established itself as a core technique in the early stage of drug discovery for secondary compound screening. It allows several independent cellular parameters to be measured in a single cell or populations of cells

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A microfluidics platform for combinatorial drug screening

2018-6-22  For screening, the Braille valve chip (Fig. 1a) was mounted onto an SC-9 Braille display (KGS Corporation, Japan) using an in-house holder as shown in Fig. 1b. This holder includes a

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Application of microfluidic chip technology in

2019-8-1  Microfluidic chip technologies, such as lab-on-a-chip technology, three-dimensional (3D) cell culture, organs-on-chip and droplet techniques, have all been developed rapidly. Microfluidic chips coupled with various kinds of detection techniques are suitable for the high-throughput screening, detection and mechanistic study of drugs.

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Chinese scientists develop heart-on-a-chip device to aid

2018-4-11  NANJING Chinese scientists have developed a "heart-on-a-chip" device to mimic the beat and contraction of cardiac muscle cells in vitro, which could replace non-human animal models for drug screening. "Organ-on-a-chip" research mainly involves designing an inch-long silicone device that houses a network of organ cells, which can effectively

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A Precise Microfluidic Assay in Single‐Cell Profile for

2020-4-19  The on-chip screening results were all verified by the patch-clamp assay except for the inhibitory effect of the A-31 on TRPV3 channel. Therefore, the single-cell arrayed microchip dramatically reduces the false-positive/negative results of the conventional FlexStation 3 screening from 76.2% (16/21) to 4.8% (1/21).

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Characterising a PDMS based 3D cell culturing microfluidic

2020-9-28  The microfluidic device described in this study utilises the non-cell adherent properties of the PDMS flow chip located between two layers of Poly(methyl methacrylate) (PMMA), to generate 3D

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Organ-on-a-chip Drug screenIng device to tArget braiN

2020-11-1  Brain organ-on-a-chip drug screening device. Show the project objective. Programme(s) H2020-EU.1.1. EXCELLENT SCIENCE European Research Council (ERC) Topic(s) ERC-2019-POC ERC Proof of Concept Grant ; Call for proposal. ERC-2019-PoC See other projects for this call .

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Cell 'membrane on a chip' could speed up screening of

2020-7-6  The device will speed up the screening of drug candidates and provide answers to questions about how this virus works," said Dr. Han-Yuan Liu, Cornell researcher and joint first author on both papers.

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New on-chip screening of gate oxides smart power devices

2009-4-30  Efficient screening procedures for the control of the gate oxide defectivity are vital to limit early failures especially in critical automotive applications. Traditional strategies based on burn-in and in-line tests are able to provide the required level of reliability but they are expensive and time consuming. This paper presents a novel approach to the gate stress test of lateral diffused

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New on-chip screening of gate oxides smart power devices

New on-chip screening of gate oxides smart power devices for automotive applications Based on data of more than 30 million sold devices, the effect of screening of latent defects at electrical

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Cells on chip for multiplex screening ScienceDirect

2016-2-15  Microfluidic chip reversibly bond with a PDMS-coated glass substrate and was used as an “Ip-Do Assay” device. To synthesize the gold nanofilm on PDMS as a strip-pattern, gold(III) chloride solution was delivered into the chip and incubated to conduct the reduction reaction, followed by human fibronectin incubation and blow-drying.

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Chinese scientists develop heart-on-a-chip device to aid

2018-4-11  NANJING Chinese scientists have developed a "heart-on-a-chip" device to mimic the beat and contraction of cardiac muscle cells in vitro, which could replace non-human animal models for drug screening. "Organ-on-a-chip" research mainly involves designing an inch-long silicone device that houses a network of organ cells, which can effectively

get price

A microfluidics platform for combinatorial drug screening

2018-6-22  For screening, the Braille valve chip (Fig. 1a) was mounted onto an SC-9 Braille display (KGS Corporation, Japan) using an in-house holder as shown in Fig. 1b. This holder includes a

get price

A Rapid Screening Method for Wound Dressing by

2012-6-8  A Rapid Screening Method for Wound Dressing by Cell‐on‐a‐Chip Device Qilong Zhao CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China

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Recent advances in microfluidic devices for bacteria and

2019-3-1  Recently, benefiting from the development of microfluidic chip and mass spectrometry, chip-mass spectrometry (Chip-MS) has become an ambient platform for cell analysis . In perspective, Chip-MS will also contribute to the study of microbial metabolism, clinical diagnosis and treatment of diseases, and drug screening.

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Characterising a PDMS based 3D cell culturing microfluidic

2020-9-28  The microfluidic device described in this study utilises the non-cell adherent properties of the PDMS flow chip located between two layers of Poly(methyl methacrylate) (PMMA), to generate 3D

get price

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